***HOORAY MONDAY GMT***
- Thread starter Pesqueeb
- Start date
Coffee...
Fucking jetlag. 
yohohohohohoho
welcome to mondb0rk
today is Friday
leaving for Tennessee tomorrow morning, week of boating / waterskiing / shenanigans in front of me
welcome to mondb0rk
today is Friday
leaving for Tennessee tomorrow morning, week of boating / waterskiing / shenanigans in front of me
I agree with the coffee comments. It's nice to see the wife managed to have a good time mountain biking in Vermont for four days this weekend while I worked. And it absolutely kills me to say that I got a shitload of work done during said weekend and walked into work this morning with this project in great shape. Goddamn work.
So I saw my physical therapist guy Saturday afternoon to get my angry calf looked at. Turns out it's related to a hamstring problem that I didn't know I had. But I told him, I said "Look, my hamstring doesn't hurt" and he said "Oh yeah, how does this feel?" and he jammed his finger into a hamstring tendon and I was like "HOLY FUCKING SHIT!!" I asked him if that was normal so he did the same thing to my other leg and I felt nothing. Damn. So I just need to roll and stretch the hell out of it. He said it's going to hurt for a while but it'll go away if I keep working on it, and he told me to keep running and biking through it so I don't lose fitness. Then he didn't charge me for the visit.
So I saw my physical therapist guy Saturday afternoon to get my angry calf looked at. Turns out it's related to a hamstring problem that I didn't know I had. But I told him, I said "Look, my hamstring doesn't hurt" and he said "Oh yeah, how does this feel?" and he jammed his finger into a hamstring tendon and I was like "HOLY FUCKING SHIT!!" I asked him if that was normal so he did the same thing to my other leg and I felt nothing. Damn. So I just need to roll and stretch the hell out of it. He said it's going to hurt for a while but it'll go away if I keep working on it, and he told me to keep running and biking through it so I don't lose fitness. Then he didn't charge me for the visit.
Waiting for stone chips in van windshield to be repaired.
the sprinter?
WINDROCK IT NAO!!!!1!1!1!1!111!1!!!!yohohohohohoho
welcome to mondb0rk
today is Friday
short shift today 8:30 to 3:30 so I should be able to get in a ride this afternoon
In the meantime my coffee is hitting the spot
In the meantime my coffee is hitting the spot
I work with morons. I had 4 guys on a minimum four hour call to help install a set. The guy leading the install sends the freelancers home after 2 hours, and he then puts a new man on the job, for a minimum four hour call, to help him for an hour.
Edit to add FTS
Edit to add FTS
OMG. Work. FTS. With a giant, pointy stick covered in Texan fire ants.
I thought of IAB immediately when I saw this blurb re transplanting biomes from athletes poop to enhance my own "crappy" physical capabilities:
#andyesitcomesinrootbeer
https://www.npr.org/sections/health-shots/2019/06/24/734826163/elite-runners-gut-microbe-makes-mice-more-athletic-could-it-help-the-rest-of-us
Could A Microbe Boost Athletic Performance?
June 24, 201911:53 AM ET
JONATHAN LAMBERT
Researchers studied the gut microbes of runners from the Boston Marathon, isolating one strain of bacteria that may boost athletic performance.
Nicolaus Czarnecki/Boston Herald via Getty Images
Competitive runners (myself included, once upon a time) will try almost anything that could give them a natural edge in their next 5K or 10K.
Down concentrated beet juice before a race? I've done it.
But new research hints that, perhaps, someday I may add consuming bacteria to that list.
A new study out Monday in the journal Nature Medicineidentified a group of bacteria that are more common in athletes, especially after exercise, and may play a role in enhancing athletic performance. The researchers isolated this bacterial strain from elite runners, put it into the colons of lab mice and found that these human-derived bacteria boosted the mouse's performance on a treadmill exertion test by 13%.
"This is a really impressive study," says Morgan Langille, a microbiome researcher at Dalhousie University in Nova Scotia who was not involved in the research. "It's the first study I'm aware of that goes beyond correlation to show that certain microbes that increase with exercise actually have an effect [on performance]."
Article continues after sponsor message
already knew that exercise subtly changes the makeup of our microbiome. Certain strains flourish in the post-workout gut. But scientists hadn't demonstrated whether any of these exercise-loving microbes actually affect our health or performance.
"If we could identify microbes that do contribute to the health and performance of super healthy people, then maybe we could develop a probiotic to help everyday people perform better," says Jonathan Scheiman, currently the co-founder and CEO of FitBiomics, who led this study while he was a postdoctoral researcher at Harvard Medical School.
For the research, Scheiman would need a good data set of the gut microbes of athletes. So he solicited Boston Marathon runners for their poop.
"A good two weeks of my life was spent driving around Boston in a Zipcar collecting fecal samples from runners," Scheiman says. He wanted to compare their microbes before and after running the marathon, and weigh them against the microbiomes of non-runners.
Scheiman handed off the stool samples to his colleague Aleksandar Kostic, a microbiologist at the Harvard Medical School-affiliated Joslin Diabetes Center (Kostic is also a co-founder and science adviser for FitBiomics). Kostic sequenced the bacterial DNA in the stool samples and looked for differences — either in the kinds of bacteria present or their relative numbers — between the groups.
The differences were subtle. "It's not as though that the microbiome of runners looks completely different from nonrunners," he says. "But one group of bacteria stood out in runners. Veillonella."
Veillonella bacteria seemed to be a bit more common in runners than nonrunners, and it became much more common in the guts of runners after they'd run the marathon.
"We were intrigued, but I didn't know anything about Veillonella," says Scheiman. "So I Googled it."
Wyss Institute at Harvard University
He learned that Veillonella has a fairly unusual way of making a living — it eats lactate, a chemical byproduct of intense exercise that's associated with fatigue (though, contrary to popular belief, it doesn't actually cause your muscles to hurt).
Scheiman's intrigue grew. "Isn't it interesting that after running a race you have an increase in a kind of bacteria that eats a metabolic byproduct of running a race? ... That was a big lightbulb moment," he says.
At this point, all the researchers had was an interesting correlation. It was a good start, but not enough according to Kostic: "We wanted to understand exactly what Veillonella is doing." Specifically, the researchers wondered if the bacteria might be boosting endurance performance.
So they did an experiment.
Scheiman isolated Veillonellafrom the stool of one of the marathoners and transferred it into the guts of normal laboratory mice. As a control, he inoculated another group of mice with a different strain of non-lactate eating bacteria.
Then, the two groups faced off in a series of races to exhaustion run on a mouse treadmill.
The Veillonella-treated mice won. On average, they lasted 13% longer (~18 minutes vs. ~16 minutes across all trials) than the control mice.
"We were pretty surprised to see that big of an effect from a [human-derived] bacteria," Scheiman says. "Imagine telling a marathon runner that you could improve their performance by 13%. It'd be huge."
Of course, a 13% boost in one measure of performance in mice does not directly apply to humans. But the researchers wanted to know how bacteria living in the gut (not in muscles or lungs, tissues directly involved in exercise) improved performance in mice so significantly.
The research team thought it might have something to do with how Veillonella breaks down lactate.
Our liver processes excess lactate by converting it to glucose, but Veillonella does something different. It gobbles up lactate and converts it into a molecule called propionate, a short-chain fatty acid that's been shown to affect heart rate and oxygen absorption in mice.
With this in mind, the researchers transferred pure propionate to the guts of mice and ran the same treadmill test. "Lo and behold, propionate produced the same endurance boost as Veillonella," Scheiman says. The researchers found the mechanism. Veillonella enhances the performance of its host by converting lactate to propionate.
But why the bacteria do this is a harder question to answer.
"Athletes that exercise often may simply be creating a gut with higher levels of lactate that allow Veillonella to flourish," Scheiman says. Veillonella might even be pumping out propionate in order to boost the performance of its host in a symbiotic tit-for-tat, according to Scheiman, though that's far from clear. Either way, Scheiman is hoping athletes may some day be able to benefit from its relationship with our guts.
Since conducting this research, he left academia to run the company FitBiomics. "Our mission is to mine the biology of the most fit and healthy people in the world and then aim to translate that data into ... next-generation probiotics," he says. He hopes to start testing Veillonella in human subjects with the ultimate goal of creating an endurance-boosting probiotic.
Langille is a bit more skeptical that someday soon you'll be able to pop Veillonella pill to get a fitness boost. "This research certainly opens the door to that possibility, but often it's harder to replicate an effect you see in mice in human studies," he says.
Langille also suggests that since Veillonella already seems to be more common in athletes, further supplementation may not translate into better performance.
Additionally, while scientists agree there is some evidencethat certain probiotics can help people with digestive problems like irritable bowel syndrome, many scientists argue that there's not yet convincing evidence that they help healthy people.
"Still, before this study I don't think anyone would've said that the microbiome could boost athletic performance," Langille says. "It's an intriguing concept."
That's a really fun itinerary for a family with 3 small kids. Don't ask me how I know.
That's a really fun itinerary for a family with 3 small kids. Don't ask me how I know.
if you are sarcastic.My kids love trains, and they love ice cream. And cows. What could go wrong?
My kids love trains, and they love ice cream. And cows. What could go wrong?
There are three icecream shops near my house. Pretty much every time I walk by one I hear a child screaming bloody murder.
Nope. No sarcasm. That's a fun day. And the creamery... that kept them entertained for hours. Mmmm... Tillamook cheese...
My kids love trains, and they love ice cream. And cows. What could go wrong?
Girlfriend’s dad was admitted to the ICU last night, with multiple organ failures starting to occur. She’s on a plane to Rhode Island with her other sister who lives in CO, heading to visit him. Gonna maybe be a weird week.
Dislike
booooooo
No bueno, hope for the best.
TL;DR
I thought of IAB immediately when I saw this blurb re transplanting biomes from athletes poop to enhance my own "crappy" physical capabilities:
#andyesitcomesinrootbeer
https://www.npr.org/sections/health-shots/2019/06/24/734826163/elite-runners-gut-microbe-makes-mice-more-athletic-could-it-help-the-rest-of-us
Could A Microbe Boost Athletic Performance?
June 24, 201911:53 AM ET
JONATHAN LAMBERT
Researchers studied the gut microbes of runners from the Boston Marathon, isolating one strain of bacteria that may boost athletic performance.
Nicolaus Czarnecki/Boston Herald via Getty Images
Competitive runners (myself included, once upon a time) will try almost anything that could give them a natural edge in their next 5K or 10K.
Down concentrated beet juice before a race? I've done it.
But new research hints that, perhaps, someday I may add consuming bacteria to that list.
A new study out Monday in the journal Nature Medicineidentified a group of bacteria that are more common in athletes, especially after exercise, and may play a role in enhancing athletic performance. The researchers isolated this bacterial strain from elite runners, put it into the colons of lab mice and found that these human-derived bacteria boosted the mouse's performance on a treadmill exertion test by 13%.
"This is a really impressive study," says Morgan Langille, a microbiome researcher at Dalhousie University in Nova Scotia who was not involved in the research. "It's the first study I'm aware of that goes beyond correlation to show that certain microbes that increase with exercise actually have an effect [on performance]."
Article continues after sponsor message
already knew that exercise subtly changes the makeup of our microbiome. Certain strains flourish in the post-workout gut. But scientists hadn't demonstrated whether any of these exercise-loving microbes actually affect our health or performance.
"If we could identify microbes that do contribute to the health and performance of super healthy people, then maybe we could develop a probiotic to help everyday people perform better," says Jonathan Scheiman, currently the co-founder and CEO of FitBiomics, who led this study while he was a postdoctoral researcher at Harvard Medical School.
For the research, Scheiman would need a good data set of the gut microbes of athletes. So he solicited Boston Marathon runners for their poop.
"A good two weeks of my life was spent driving around Boston in a Zipcar collecting fecal samples from runners," Scheiman says. He wanted to compare their microbes before and after running the marathon, and weigh them against the microbiomes of non-runners.
Scheiman handed off the stool samples to his colleague Aleksandar Kostic, a microbiologist at the Harvard Medical School-affiliated Joslin Diabetes Center (Kostic is also a co-founder and science adviser for FitBiomics). Kostic sequenced the bacterial DNA in the stool samples and looked for differences — either in the kinds of bacteria present or their relative numbers — between the groups.
The differences were subtle. "It's not as though that the microbiome of runners looks completely different from nonrunners," he says. "But one group of bacteria stood out in runners. Veillonella."
Veillonella bacteria seemed to be a bit more common in runners than nonrunners, and it became much more common in the guts of runners after they'd run the marathon.
"We were intrigued, but I didn't know anything about Veillonella," says Scheiman. "So I Googled it."
Wyss Institute at Harvard University
He learned that Veillonella has a fairly unusual way of making a living — it eats lactate, a chemical byproduct of intense exercise that's associated with fatigue (though, contrary to popular belief, it doesn't actually cause your muscles to hurt).
Scheiman's intrigue grew. "Isn't it interesting that after running a race you have an increase in a kind of bacteria that eats a metabolic byproduct of running a race? ... That was a big lightbulb moment," he says.
At this point, all the researchers had was an interesting correlation. It was a good start, but not enough according to Kostic: "We wanted to understand exactly what Veillonella is doing." Specifically, the researchers wondered if the bacteria might be boosting endurance performance.
So they did an experiment.
Scheiman isolated Veillonellafrom the stool of one of the marathoners and transferred it into the guts of normal laboratory mice. As a control, he inoculated another group of mice with a different strain of non-lactate eating bacteria.
Then, the two groups faced off in a series of races to exhaustion run on a mouse treadmill.
The Veillonella-treated mice won. On average, they lasted 13% longer (~18 minutes vs. ~16 minutes across all trials) than the control mice.
"We were pretty surprised to see that big of an effect from a [human-derived] bacteria," Scheiman says. "Imagine telling a marathon runner that you could improve their performance by 13%. It'd be huge."
Of course, a 13% boost in one measure of performance in mice does not directly apply to humans. But the researchers wanted to know how bacteria living in the gut (not in muscles or lungs, tissues directly involved in exercise) improved performance in mice so significantly.
The research team thought it might have something to do with how Veillonella breaks down lactate.
Our liver processes excess lactate by converting it to glucose, but Veillonella does something different. It gobbles up lactate and converts it into a molecule called propionate, a short-chain fatty acid that's been shown to affect heart rate and oxygen absorption in mice.
With this in mind, the researchers transferred pure propionate to the guts of mice and ran the same treadmill test. "Lo and behold, propionate produced the same endurance boost as Veillonella," Scheiman says. The researchers found the mechanism. Veillonella enhances the performance of its host by converting lactate to propionate.
But why the bacteria do this is a harder question to answer.
"Athletes that exercise often may simply be creating a gut with higher levels of lactate that allow Veillonella to flourish," Scheiman says. Veillonella might even be pumping out propionate in order to boost the performance of its host in a symbiotic tit-for-tat, according to Scheiman, though that's far from clear. Either way, Scheiman is hoping athletes may some day be able to benefit from its relationship with our guts.
Since conducting this research, he left academia to run the company FitBiomics. "Our mission is to mine the biology of the most fit and healthy people in the world and then aim to translate that data into ... next-generation probiotics," he says. He hopes to start testing Veillonella in human subjects with the ultimate goal of creating an endurance-boosting probiotic.
Langille is a bit more skeptical that someday soon you'll be able to pop Veillonella pill to get a fitness boost. "This research certainly opens the door to that possibility, but often it's harder to replicate an effect you see in mice in human studies," he says.
Langille also suggests that since Veillonella already seems to be more common in athletes, further supplementation may not translate into better performance.
Additionally, while scientists agree there is some evidencethat certain probiotics can help people with digestive problems like irritable bowel syndrome, many scientists argue that there's not yet convincing evidence that they help healthy people.
"Still, before this study I don't think anyone would've said that the microbiome could boost athletic performance," Langille says. "It's an intriguing concept."
hooray depression. :/
meh weekend.
took the girls to water world. god i hate that place.
meh weekend.
took the girls to water world. god i hate that place.
Morning Monkeys.
Looks like a weird week with Thursday off and working Friday because money.
So the man child moved out on Saturday. He hadn't said anything all week about needing help, or wanting to use the truck. He asked the wife Saturday morning, she said yes as I am driving it to storage to swap for Frita.
I take my car to swap for the truck when I got home with Frita. After loading it up, he asks "is there a time that works best for you?" I said the sooner you bring the truck back, the sooner I can get my car back.
He says "oh, you weren't going to drive it over?" He didn't ask, so I didn't plan to. So he left, brought it back with a 1/4 tank left and left in his car.
He said nothing to me or the wife. After nearly 30 months of living here, no "thanks and stuff". I know not to expect it, but it was still odd and really hurt. I would say "kids these days" but he's fucking 33.
/notcoolstorybro
Looks like a weird week with Thursday off and working Friday because money.
So the man child moved out on Saturday. He hadn't said anything all week about needing help, or wanting to use the truck. He asked the wife Saturday morning, she said yes as I am driving it to storage to swap for Frita.
I take my car to swap for the truck when I got home with Frita. After loading it up, he asks "is there a time that works best for you?" I said the sooner you bring the truck back, the sooner I can get my car back.
He says "oh, you weren't going to drive it over?" He didn't ask, so I didn't plan to. So he left, brought it back with a 1/4 tank left and left in his car.
He said nothing to me or the wife. After nearly 30 months of living here, no "thanks and stuff". I know not to expect it, but it was still odd and really hurt. I would say "kids these days" but he's fucking 33.
/notcoolstorybro
Millenials, amirite?
boooooooooo on that
oh jesus. Don't get me started.Hey... it may be hot and crowded, but at least the water is full of e coli.
Water world? Aren't you in the desert?!
Today is Canada Day (shout out to ask the Canaderpians, hope you're enjoying this fine day as much as I). Got out for a ride this morning before it got to hot. Did a familiar loop, but rode a new trail that had been decommissioned, and seems to be open again... With a new re-route down a knife edge ridge. It's fast and loamy up top, and has a few awesome slabs on the way down. It was so good.
The new tires, grips, and cleats were great. Going to have to get used to having grip again!
When I got home I realized I had forgotten to plan for lunch. So I boiled up a couple of hot dogs that were in the freezer and used the waffles we made for breakfast at buns. Not bad. At least I have the essentials... Booze!
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not no more!Water world? Aren't you in the desert?!
Today is Canada Day (shout out to ask the Canaderpians, hope you're enjoying this fine day as much as I). Got out for a ride this morning before it got to hot. Did a familiar loop, but rode a new trail that had been decommissioned, and seems to be open again... With a new re-route down a knife edge ridge. It's fast and loamy up top, and has a few awesome slabs on the way down. It was so good.
The new tires, grips, and cleats were great. Going to have to get used to having grip again!
When I got home I realized I had forgotten to plan for lunch. So I boiled up a couple of hot dogs that were in the freezer and used the waffles we made for breakfast at buns. Not bad. At least I have the essentials... Booze!
Nope, the Express. We were traveling in two vehicles the past couple of days - following crew informed me that if I'm accelerating hard or pulling hard uphill, it is emitting some white smoke. Sprinter's supposed to show soon...
Buck up, bucko!
The kiddos might appreciate feeding the animals at the Blue Heron Cheese Company.
Also, if you happen to make it down to Newport, eat at Local Oceans. Absolutely fabulous seafood.
Please, sir. "Semi-arid"...Water world? Aren't you in the desert?!
Mornin!
Currently hanging out in Canmore surrounded by Canada day parades. Kinda weird being in a foreign country while they celebrate their country.
Moraine Lake was ridiculous. Went for sunset last night and the traffic was just as incredible as the view.
Currently hanging out in Canmore surrounded by Canada day parades. Kinda weird being in a foreign country while they celebrate their country.
Moraine Lake was ridiculous. Went for sunset last night and the traffic was just as incredible as the view.
Good news on the luggage-front: one bag in DEN and scheduled for delivery to the Haus this afternoon.
Other bag located in ORD and scheduled for "transfer" to DEN to be delivered in the (hopefully) not-too-distant future.
It *looks* like the bag currently scheduled for delivery is the one with the guanciale.
Other bag located in ORD and scheduled for "transfer" to DEN to be delivered in the (hopefully) not-too-distant future.
It *looks* like the bag currently scheduled for delivery is the one with the guanciale.
