I prefer locktite because I always have some. Grease in time will wash away and the nipples can seize. Locktite seals better for longer. The reason you use a thread lock is not just to keep the threads from seizing, but for holding the nipple in place when all the tension comes off the spoke when you hit something hard enough to flex the rim sideways or even up.
I use grease on the eyelets (where I want a lasting lubricant). and Tri-Flow on the threads. Why such a light lube? Well it doesn't electrolysize or attract much dirt. It can be re applied every time you true your wheels and will penetrate down into the threads even when the wheel is fully tensioned.
You can add a little water to dry spoke prep and it comes back just fine.
I completely disagree that spoke prep is a crutch for bad wheel builders, it's usually bad wheel builders that don't use any kind of prep because they take short-cuts. All wheels flex all the time. If the threads are lubed things will de-tension much faster. That's my (20 plus years) experience anyway.
Prep the threads, a drop of tri-flow on the eyelets, build the wheel without enough delay for the prep to dry before you're done. That way you can tension the wheel easily, and it will hold that tension for a long long long time.
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