COVID-19 Update: Stay-at-Home Order's End Won't Be As You Hoped
Not all businesses will be open again on April 27.
Things half back to normal come May 5 in Colorado. Sounds like a sane plan to me.
CoVID-19
Things half back to normal come May 5 in Colorado. Sounds like a sane plan to me.
Bummer, then there's now way they'll let it happen then.
43 vented C19 patients at the moment, down from our high of 60 or so. We have six CRRT machines, with 8-10 patients needed CVVHD. So they are getting a shift or two each, then the machine gets swapped to someone else.
Vents and PPE we are doing OK with for the time being. Granted, we are trying to conserve as much as possible. We've a much larger supply of PAPRs now, and many more of us are using respirator masks, or longer use P95 masks that we already had.
We'll see if this is just a momentary dip or something more long term. I suspect we'll see a nice long wave of ups and downs for some while.
Am honestly surprised we haven't gotten nailed as badly as we feared, especially being only an hour away from NYC.
Vents and PPE we are doing OK with for the time being. Granted, we are trying to conserve as much as possible. We've a much larger supply of PAPRs now, and many more of us are using respirator masks, or longer use P95 masks that we already had.
We'll see if this is just a momentary dip or something more long term. I suspect we'll see a nice long wave of ups and downs for some while.
Am honestly surprised we haven't gotten nailed as badly as we feared, especially being only an hour away from NYC.
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Interesting episode.
Making Sense with Sam Harris: #195 — Social Cohesion is Everything on Apple Podcasts
Show Making Sense with Sam Harris, Ep #195 — Social Cohesion is Everything - Apr 6, 2020
podcasts.apple.com
Our overall numbers are similarly down a bit from the peak last week. (Local maximum?) Still 3 on ECMO + similar count of vented.
We didn't start any ECMO - my little place only has two setups, not counting the CT surg OR setup, so they really didn't want to go there...
We've been doing a lot of proning. Heparin protocol for all the elevated d-dimers, Levo/Vaso/Propo trifecta for nearly everyone.
Man Who Called Ohio's Lockdown Order 'Bullshit' Has Succumbed To COVID-19
John McDaniel railed on social media against Ohio's Gov. Mike DeWine's lockdown order. Weeks later he contracted the virus. A few days ago he died.crooksandliars.com
Bloomberg - Are you a robot?
www.bloomberg.com
Same rules apply here. If the environmental monitoring shows particles you have to discard everything that was handled at the time. The training our students receive are more for hospital pharmacy cleanrooms though where personalized drugs for e.g. cancer treatment are mixed. Lower financial but higher personal consequences.
I know. In Europe cleanrooms are regulated by the EU GMP classification with classes D to A. For pharmaceutical production this is outlined in the European Pharmacopoeia if you are interested.
Sounds like teh brian-dead crowd needs to shutdown downtown again, then!COVID-19 Update: Stay-at-Home Order's End Won't Be As You Hoped
Not all businesses will be open again on April 27.www.westword.com
Things half back to normal come May 5 in Colorado. Sounds like a sane plan to me.
Opinion | The Infection That’s Silently Killing Coronavirus Patients (Published 2020)
This is what I learned during 10 days of treating Covid pneumonia at Bellevue Hospital.
She already looked like a bad guy from a shelved Power Rangers movie. The glowing eyes really turn it up though.
"Super Atomic #MAGA Karen attacks!"
How Abortion, Guns and Church Closings Made Coronavirus a Culture War https://nyti.ms/2KhEUed
Everything gets co-opted by the culture war.
Never let a tragedy go to waste is the universal playbook.
Same here. She's a senior anyway.
well.. some official data in developing countries.
Day 37 of lockdown. It was reported today 42% of the people in the contry has no job or zero income at this point.
Thousands have been seen walking 200-300 miles (!), leaving the main cities and moving to back to the countryside (supposedly to the house of family members as they cant afford housing/food anymore).
Day 37 of lockdown. It was reported today 42% of the people in the contry has no job or zero income at this point.
Thousands have been seen walking 200-300 miles (!), leaving the main cities and moving to back to the countryside (supposedly to the house of family members as they cant afford housing/food anymore).
reminds me of our discussion about ensuring things work before they get shoved on the market without appropriate vetting.
Feud over Stanford coronavirus study: ‘The authors owe us all an apology’
Did the COVID-19 virus infect between 48,000 and 81,000 residents of Santa Clara County? Not so quick, say statisticians, citing what they call deep flaws in a Stanford study.
www.mercurynews.com
Excellent article for the lay press!
Statistician John Cherian of D. E. Shaw Research, a computational biochemistry company, made his own calculations given the test’s sensitivity and specificity — and estimated the proportion of truly positive people in the Stanford study to range from 0.5% to 2.8%.
Adjusting for demographics, Cherian’s calculations suggest that prevalence could plausibly be under 1% and the mortality rate could be over 1%.
The “confidence intervals” in the paper – that is, the range around a measurement that conveys how precise the measurement is – “are nowhere close to what you’d get with a more careful approach,” he noted.
Assuming a sensitivity of 72%, this is a histogram of possible true positive rates, according to statistician John Cherian.
Even if the test were completely accurate, there would still be sampling problems in the Stanford study, critics said.
n= 368 male vets, 3 arms (control, HCQ, HCQ + AZ). Not randomized but retrospective cohort with propensity score adjustment.
Hazard ratio of death in HCQ vs control group was 2.61 (1.10-6.17). HR of death of HCQ + AZ vs control group was 1.14 (0.56-2.32, p=0.72).
"increased risk of overall mortality in the hydroxychloroquine-only group persisted after
adjusting for the propensity of being treated with the drug."
"That there was no increased risk of ventilation in the hydroxychloroquine-only group suggests that mortality in this group might be attributable to drug effects on or dysfunction in non-respiratory vital organ systems."
(If this sounds like a negative trial to you then good, you've comprehended the message.)
and there will be no repercussions for those pushing it.
There will be for us.
Kentucky reports highest coronavirus infection increase after a week of protests to reopen state
"We are still in the midst of this fight against a deadly and highly contagious virus," Kentucky Governor Andy Beshear said.
www.newsweek.com
Because the chief purveyor of this lunacy will still be in charge of it all.
just because he says it doesn't you mean you have to do it
quite the opposite, in fact.
The Pandemic’s Hidden Toll: Half a Million Deaths (Published 2020)
Far more people died in 2020 during the pandemic than have been officially reported, a review of mortality data in 35 countries shows.
www.nytimes.com
???
This product went through all of the rigor of any other FDA device. Accelerated doesn't mean corners cut. It means you have FDA on speed dial and your submissions and information requests get as immediate response as one can get from FDA as opposed to the typical 90 day decision time for just a decision on a 510k which completely ignores all of the other long lead bureaucratic interaction one can have with the FDA prior to a 510k submission.
Full verification and to the extent one can conduct validation also occurred (obviously no notable time has passed for useful post market surveillance etc).
Lastly, to my awareness this test never claimed sensitivity to low viral load, but elevated levels, and some tests will lose sensitivity if below certain levels. This is why RNA PCR testing is the gold standard and why testing has been such a shitshow. I would need to see the product insert to assess the final claims, but Abbott has too much riding on the line to BS.
My issue and why I originally brought up the Abbott 5 minute test was because every god damn politician and sports league commissioner was talking about this test as if it was going to transform detection of the virus without understanding the science, claims, and uses. The test still serves a purpose, but until benchtop automated rapid PCR equipment and assays get FDA clearance, exisiting equipment is reconfigured, and new units are built and distributed we're stuck with manual/lab equipment test methods. Thankfully I'm aware that FDA is approving some of these new machines so the process of rejiggering and distributing has started.
The challenge as I see it now is that this is pretty complex equipment and as you are probably aware, low volume and high precision capital medical equipment usually requires a small army of technical product specialists in order to maintain and debug it. Now Siemens, Abbott, Quest, Thermo, etc. will be producing in far greater volumes and the number of units will exceed the capacity of their support teams. In addition to the fact that folks are pretty much grounded and travel is far more limited. Overall it's good that more equipment that can test faster will soon start to become available.
PS, my previous discussion with you was about devices not intended to be marketed.
Would you two get a room already?
how was your 4/20?
it doesn't? because what you said previously definitely is cutting corners vs a highly accelerated regulatory pathway.
You cold, cold BASTID!
On an unrelated note - the lady that was complaining about not being able to drive her ski boat on her lake just posted a link from Brietbart
that is trumpeting the results of those flawed antibody studies @Toshi referenced earlier.
Dude, that was reference to getting devices and products into a clinical setting. Very different stuff than production and marketed products....